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Management of thrombocytopenia in the ICU (pregnancy excluded)

Thierry Van der Linden1*, Bertrand Souweine2, Laurent Dupic3, Lilia Soufir4 and Pascal Meyer5

Author Affiliations

1 Service de Réanimation Polyvalente, groupe hospitalier Institut Catholique de Lille/Faculté Libre de Médecine/Université Lille Nord de France, F-59462 Lomme lez Lille, France

2 Service de Réanimation Polyvalente, CHU Gabriel Montpied, 58 rue Montalembert, F-63003 Clermont-Ferrand, France

3 Service de Réanimation Médico-Chirurgicale, CHU Necker Enfants Malades, 149, Rue de Sèvres, 75743 Paris cedex 15, France

4 Service de Réanimation Chirurgicale, Groupe Hospitalier Paris Saint Joseph, 85 rue Raymond Losserand, 75014 Paris, France

5 Service de Réanimation Polyvalente, CH Sud Francilien Site de Corbeil, 59, Boulevard Henri Dunant, 91106 Corbeil-Essonnes cedex, France

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Annals of Intensive Care 2012, 2:42  doi:10.1186/2110-5820-2-42

Published: 28 August 2012

Abstract

Thrombocytopenia is a very frequent disorder in the intensive care unit. Many etiologies should be searched, and therapeutic approaches differ according to these different causes. However, no guideline exists regarding optimum practices for these situations in critically ill patients. We present recommendations for the management of thrombocytopenia in intensive care unit, excluding pregnancy, developed by an expert group of the French-Language Society of Intensive Care (Société de Réanimation de Langue Française (SRLF), the French Language Group of Paediatric Intensive Care and Emergencies (GFRUP) and of the Haemostasis and Thrombosis Study Group (GEHT) of the French Society of Haematology (SFH). The recommendations cover six fields of application: definition, epidemiology, and prognosis; diagnostic approach; therapeutic aspects; thrombocytopenia and sepsis; iatrogenic thrombocytopenia, with a special focus on heparin-induced thrombocytopenia; and thrombotic microangiopathy.

Keywords:
Thrombocytopenia; Critical care; Adults; Expert recommendations