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Open Access Research

Sleep quality in mechanically ventilated patients: comparison between NAVA and PSV modes

Stéphane Delisle123*, Paul Ouellet345, Patrick Bellemare1, Jean-Pierre Tétrault3 and Pierre Arsenault3

Author Affiliations

1 Service des soins intensifs, Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada

2 Département de médecine familiale et d'urgence, Université de Montréal, Montréal, Québec, Canada

3 Département des sciences cliniques, Université de Sherbrooke, Sherbrooke, Québec, Canada

4 Département de chirurgie, Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Québec, Canada

5 Service des soins intensifs, Hôpital régional d'Edmundston, réseau de santé Vitalité, Edmundston, Nouveau-Brunswick, Canada

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Annals of Intensive Care 2011, 1:42  doi:10.1186/2110-5820-1-42

Published: 28 September 2011

Abstract

Background

Mechanical ventilation seems to occupy a major source in alteration in the quality and quantity of sleep among patients in intensive care. Quality of sleep is negatively affected with frequent patient-ventilator asynchronies and more specifically with modes of ventilation. The quality of sleep among ventilated patients seems to be related in part to the alteration between the capacities of the ventilator to meet patient demand. The objective of this study was to compare the impact of two modes of ventilation and patient-ventilator interaction on sleep architecture.

Methods

Prospective, comparative crossover study in 14 conscious, nonsedated, mechanically ventilated adults, during weaning in a university hospital medical intensive care unit. Patients were successively ventilated in a random ordered cross-over sequence with neurally adjusted ventilatory assist (NAVA) and pressure support ventilation (PSV). Sleep polysomnography was performed during four 4-hour periods, two with each mode in random order.

Results

The tracings of the flow, airway pressure, and electrical activity of the diaphragm were used to diagnose central apneas and ineffective efforts. The main abnormalities were a low percentage of rapid eye movement (REM) sleep, for a median (25th-75th percentiles) of 11.5% (range, 8-20%) of total sleep, and a highly fragmented sleep with 25 arousals and awakenings per hour of sleep. Proportions of REM sleep duration were different in the two ventilatory modes (4.5% (range, 3-11%) in PSV and 16.5% (range, 13-29%) during NAVA (p = 0.001)), as well as the fragmentation index, with 40 ± 20 arousals and awakenings per hour in PSV and 16 ± 9 during NAVA (p = 0.001). There were large differences in ineffective efforts (24 ± 23 per hour of sleep in PSV, and 0 during NAVA) and episodes of central apnea (10.5 ± 11 in PSV vs. 0 during NAVA). Minute ventilation was similar in both modes.

Conclusions

NAVA improves the quality of sleep over PSV in terms of REM sleep, fragmentation index, and ineffective efforts in a nonsedated adult population.